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Melatonin is primarily considered a direct messenger, as it is a hormone that is released into the bloodstream and directly affects target cells by binding to specific receptors. It plays a crucial role in regulating circadian rhythms and sleep-wake cycles. While it can influence intracellular signaling pathways, it does not function as a second messenger like cyclic AMP or calcium ions, which relay signals within cells after an initial stimulus.

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Does direct gene activation involve a second-messenger system?

No, direct gene activation typically does not involve a second-messenger system. Direct gene activation involves specific transcription factors binding directly to gene promoter regions to regulate gene expression. Second-messenger systems are typically involved in signal transduction pathways that lead to changes in protein activity or cell function, rather than directly activating genes.


What does a second messenger always do?

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Possible activation of several different second messenger systems.


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Steroid hormones act in the transcriptional level in the nucleus of a cell, due to their ability to travel through cell membranes (hydrophillic). Second messengers are necessary for hormones that cannot penetrate cell membranes (peptides).


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Steroid hormones, such as cortisol and testosterone, do not act by a second messenger system. Instead, they pass through the cell membrane and bind to intracellular receptors, leading to direct modulation of gene expression. This mechanism allows them to influence cellular function by altering protein synthesis rather than relying on secondary messengers to relay signals.


What is the difference between bio melatonin and melatonin?

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In mammals the second messenger nitric oxide is produced from?

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Which of the following does not act as a second messenger in the second messenger system calmodulin or inositol triphosphate or cyclic AMP?

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What is the difference between first messenger and second messenger?

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Melatonin is secreated by the pineal gland.