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A multivitamin contains some nutrients that should not be taken on an empty stomach. That could be the reason nausea is experienced. To avoid that, take vitamins with food.

Another explanation:

Ok. So I'm a medical student and feel extreme nausea every time i take my multi vitamin on an empty stomach. This is usually easily resolved by popping some food in my mouth. I've noticed, the higher the fat content of the food i eat, the faster the feeling goes away. So here is my educated physiology asnwer to this question.

Nausea/vomitting is not well understood, but there are vomitting centers in your brainstem that respond both to chemoreceptors (toxins/Allergies/etc) and to motion (from your ear).

What happens when you eat a multivit, is you take a very large dose of essential ions, 'vital amines', and sometimes metals such as zinc and iron. all of these are necessary for your bodys daily use, but taken in large amounts set off toxin triggers in your brain.

Eating food dilutes the effects of these more 'toxic' necessities and your brain doesn't see the amount you just ingested as harmful. I believe that some of these components are most likely fat soluble, and therefore eating something with some fat such as yogurt or cheese allows for even faster dilution of your multi vitamin.

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11y ago

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