There are 368 miles between Tallahassee, FL, and Asheville, NC (as the bird flies).
240 West 26 East 185 South 85 South 285 South 675 South 75 South 475 South 75 South Those interstates will get you as far as Tifton. After that, Rte, 319 takes you into Tallahassee.
It is 638.16 miles.
251 mi
85 miles
84 miles
The shortest driving distance is 434 miles.
There are 57 miles between Spartanburg, SC, and Asheville, NC (as the bird flies).
Traveling on I-40 it takes at least 2 hours and 43 minutes to go the 158.87 miles between Monroe, NC and Asheville, NC.
Traveling on I-40 it takes at least 3 hours and 41 minutes to go the 224.36 miles between Durham, NC and Asheville, NC.
691 miles
It is 639.36 miles according to MapQuest.
Via I-95 and I-26 for a 9 hour drive.