How far is Lake City FL to Melbourne FL?

Answer 1

238 miles taking this route:

1. Take I-10 EAST from Lake City to I-95 SOUTH to Daytona Beach via I-295 SOUTH to bypass JACKSONVILLE (EXIT 356 off I-10 to get onto I-295, follow signs on the exit ramp to I-295 SOUTH to DAYTONA BCH ; EXIT 61A off I-295 to get onto I-95 SOUTH to DAYTONA BCH).
2. Take I-95 SOUTH to Melbourne.

Answer 2

It is 377.44 miles according to MapQuest.