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123 miles taking this route:

  1. Take U.S. 25E SOUTH, from Middlesboro, to I-81 SOUTH to KNOXVILLE.
  2. Take I-81 SOUTH (8 miles) to I-40 EAST to ASHEVILLE @ EXIT 1A.
  3. Take I-40 EAST to U.S. 276 SOUTH to WAYNESVILLE @ EXIT 20 in North Carolina.
  4. Take U.S. 276 SOUTH to Waynesville.
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