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253 miles taking this route:

  1. Take U.S. 82 EAST, from Indianola, to I-20/I-59 in Alabama, near Tuscaloosa. Turn right onto the road that leads you to I-20/I-59, and then, once you are at I-20/I-59, follow signs to I-20 EAST/I-59 NORTH to BIRMINGHAM.
  2. Take I-20 EAST/I-59 NORTH to Birmingham.
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