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§The initial stage in bone production is the secretion of collagen molecules and ground substance by osteoblasts.

§The collagen monomers polymerize rapidly to form collagen fibers.

§The resultant tissue becomes osteoid

§As the osteoid is formed, some of the osteoblasts become entrapped in the osteoid and become quiescent osteocytes.

§Within a few days after the osteoid is formed, calcium salts begin to precipitate on the surfaces of the collagen fibers.

§The precipitates first appear at intervals along each collagen fiber, forming minute nidi that rapidly multiply and grow over a period of days and weeks into the finished product, hydroxyapatite crystals.

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