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Why does osmotic fragility curve have a sigmoidal curve?
The osmotic fragility curve has a sigmoidal shape because red blood cells undergo a gradual increase in fragility as the osmolarity of the surrounding solution increases. Initially, there is little change in fragility as osmolarity increases, followed by a sharp rise in fragility at a certain point, and then a plateau as the cells reach their maximum fragility.
What does low osmotic fragility means?
Osmotic fragility usually (unless otherwise mentioned) refers to the ease with which Red Blood Cells (RBCs) undergo lysis in a hypotonic solution. Before knowing what 'low osmotic fragility' means, one should know the concept of osmotic fragility. Different parameters, some of them related to the RBC and some of the extracellular environment have an effect on osmotic fragility. Low osmotic fragility means that the RBCs have a resistance against undergoing lysis when suspended in solutions which are hypotonic. They undergo lysis only if the solution is extremely hypotonic. In contrast, high osmotic fragility refers to the tendency of the RBCs to lyse even if the solution in which they are suspended in is mildly hypotonic. As an example for low osmotic fragility would be thalassemia. And as an example for high osmotic fragility, spherocytosis (a hereditary condition where the RBCs lose their usual biconcave structure and become spherical) causes increased osmotic fragility. i.e, It very easily lyses even at solutions which are mildly hypotonic... p.s Another interesting point to note is that in sickle cell anemia, the RBCs show increased mechanical fragility but decreased osmotic fragility. Elucidated by the fact that post-splenectomy the RBC lifespan increases.
What is Sigmoid?
Having the shape of the letter 'S'
What factors affect osmotic fragility tests?
Factors that affect osmotic fragility tests include the pH of the solution, temperature, duration of exposure to hypotonic solutions, and the presence of any interfering substances in the sample. Changes in these factors can alter the erythrocyte membrane permeability and impact the results of the test.
What is the sigmoid colon?
The sigmoid colon is part of the large intestine in the human body. This part is the last part of the intestine that leads to the rectum in a S-shape.
What is osmotic alterations?
Osmotic alterations can be defined as the fragility of the red blood cells in hypo and hyperthyroid patients. Changes in the concentration of the thyroid hormone can affect Na+K+ATPase number and activity and the phpspholipid composition of the cell membranes.
What does sigmoid mean in anatomy?
In anatomy, sigmoid typically refers to the S-shaped curve that is found in various structures of the body, such as the sigmoid colon in the large intestine. The term sigmoid is often used to describe structures that exhibit this distinctive S-shape.
What is the medical term meaning has a S shape?
"sigmoid" means s-shaped.
What is a large abscess in the sigmoid colon and how is it treated?
An abscess is an infected site with pus. It is treated with antibiotics. The sigmoid colon is the part where it curves around in an S shape.
What is proximal sigmoid?
The proximal sigmoid colon is the portion of the large intestine that is closest to the beginning of the sigmoid colon. It is located near the end of the descending colon and functions in absorbing water and electrolytes from the remaining digested food before it moves into the sigmoid colon for further processing.
What is the function of sigmoid?
A sigmoid is a mathematical function that is shown on a curve. It essentially shows data on a graph or chart but only ends up showing that data in the shape of an S.
What are the different methods used for osmotic fragility test?
-Acidified glycerol Lysis test - the Pink Test - NESTROFT ( naked eye single tube red cell osmotic fragility test ) :) - i tried to search this and i guess this would help other medtech students and to anyone related to it :) by: Peter Paul M. Pastor heheee!! XD
