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What does low osmotic fragility means?
Osmotic fragility usually (unless otherwise mentioned) refers to the ease with which Red Blood Cells (RBCs) undergo lysis in a hypotonic solution. Before knowing what 'low osmotic fragility' means, one should know the concept of osmotic fragility. Different parameters, some of them related to the RBC and some of the extracellular environment have an effect on osmotic fragility. Low osmotic fragility means that the RBCs have a resistance against undergoing lysis when suspended in solutions which are hypotonic. They undergo lysis only if the solution is extremely hypotonic. In contrast, high osmotic fragility refers to the tendency of the RBCs to lyse even if the solution in which they are suspended in is mildly hypotonic. As an example for low osmotic fragility would be thalassemia. And as an example for high osmotic fragility, spherocytosis (a hereditary condition where the RBCs lose their usual biconcave structure and become spherical) causes increased osmotic fragility. i.e, It very easily lyses even at solutions which are mildly hypotonic... p.s Another interesting point to note is that in sickle cell anemia, the RBCs show increased mechanical fragility but decreased osmotic fragility. Elucidated by the fact that post-splenectomy the RBC lifespan increases.
Why does osmotic fragility curve have a sigmoidal curve?
The osmotic fragility curve has a sigmoidal shape because red blood cells undergo a gradual increase in fragility as the osmolarity of the surrounding solution increases. Initially, there is little change in fragility as osmolarity increases, followed by a sharp rise in fragility at a certain point, and then a plateau as the cells reach their maximum fragility.
Why does osmotic fragility has sigmoid shape?
the cell respon differently to different solution
What factors affect osmotic fragility tests?
Factors that affect osmotic fragility tests include the pH of the solution, temperature, duration of exposure to hypotonic solutions, and the presence of any interfering substances in the sample. Changes in these factors can alter the erythrocyte membrane permeability and impact the results of the test.
In which direction does water move in a solution when there is a difference in osmotic pressure, from low to high?
In a solution with a difference in osmotic pressure, water moves from an area of low osmotic pressure to an area of high osmotic pressure.
What is osmotic alterations?
Osmotic alterations can be defined as the fragility of the red blood cells in hypo and hyperthyroid patients. Changes in the concentration of the thyroid hormone can affect Na+K+ATPase number and activity and the phpspholipid composition of the cell membranes.
Why would osmotic pressure be low in someone who is starving?
histamines.
Why would the osmotic pressure be low in someone who is starving?
histamines.
Are there other names for Thalassemia disease?
Alpha thalassemia silent carrierAlpha thalassemia minor, also called alpha thalassemia traitHemoglobin H diseaseAlpha thalassemia major, also called hydrops fetalisBeta thalassemia minor, also called beta thalassemia traitBeta thalassemia intermediaBeta thalassemia major, also called Cooley's anemia or beta-zero (ß0) thalassemiaBeta-plus (ß+) thalassemiaMediterranean anemia
What are the different methods used for osmotic fragility test?
-Acidified glycerol Lysis test - the Pink Test - NESTROFT ( naked eye single tube red cell osmotic fragility test ) :) - i tried to search this and i guess this would help other medtech students and to anyone related to it :) by: Peter Paul M. Pastor heheee!! XD
Is thalassemia a type of cancer?
Thalassemia is an autosmal recessive blood disease. That means that it is an inherited disease. Thalassemia in more common in Mediteranian people.
What are the consequences of low osmotic pressure in the human body?
Low osmotic pressure in the human body can lead to conditions such as dehydration, hypovolemia (low blood volume), and fluid imbalance. This can result in symptoms like dizziness, low blood pressure, and electrolyte imbalances, which can negatively impact the function of vital organs like the kidneys and heart.
