Advantages of Wet Granulation

Answer 1

1. Cost Effectiveness

The prime advantage of wet granulation is economic since it requires fewer unit operations. This means less equipment, lower power consumption, less space, less time and less labor leading to reduced production cost of tablets.

2. Stability

wet granulation is more suitable for moisture and heat sensitive APIs, since it eliminates drying steps and increases the stability of active ingredients

by reducing detrimental effects. Changes indissolution profiles are less likely to occur in tablets made by wet granulation on storage than in those made from granulations. This is extremely important because the official compendium now requires dissolution specifications in most solid dosage forms.

3. Faster Dissolution
Disintegration or dissolution is the rate limiting step in absorption in the case of tablets of poorly soluble API prepared by wet granulation.

4. Less wear & tear of punches
The high compaction pressure involved in the production of tablets by slugging or roller compaction can be avoided by adopting wet granulation. The chances of wear and tear of punches and dies are less.

5. Simplified Validation
Materials are "in process" for a shorter period of time, resulting in less chance for contamination or cross contamination, and making it easier to meet the requirement of current good manufacturing practices

. Due to fewer unit operations, the validation and documentation requirements are reduced.