sickle cell anaemia, thalassaemia
Gene mutations may occur in at least three Ways: they can be inherited from a parent, or acquired during a person's lifetime - See Epigenetics - or acquired during a person's lifetime - see Strontium 90.
The answer to this question depends on several things, the most important of which is the fitness evaluation. I'm going to ignore evaluation- you must determine this for yourself based on your application. Some of the things the effect the time complexity are:the data structures used to represent the individuals and the population, the genetic operators used, and the implementation of the genetic operators. Roulette wheel selection, for example, can be anywhere from O(n^2) when done naively, to O(log(n)), or even O(n) using something like Vose Alias Algorithm. The simplest case- roulette wheel selection, point mutation, and one point crossover with both individuals and populations represented by fixed length vectors- has time complexity O(gens * (mut + cross + select)) where gens is the number of generations, mut is the complexity of point mutation (n*m with n the size of the population and m the size of the individuals), cross the time complexity of crossover (n*m again), and select the time complexity of selection (n in the case of an efficiently done roulette wheel). Therefore, the time complexity of a simple Genetic Algorithm is O(gens*n*m) as this is the dominating term. I'm sure a much better explanation can be found in the literature.
Yes!! Genetic engineering is defined as the direct manipulation of an organism's genes. Though I do believe there should be some limitations on what we do with genetic engineering, it can cure so many genetic disorders and illnesses. Keep in mind that nearly EVERY human disorder has an underlying genetic cause. For instance, people with Sick Cell Anemia have a point mutation in the gene that codes for hemoglobin. This mutation results in abnormal function of the hemoglobin in their blood cells, which causes the cells to turn sickle shaped when they are deoxygenated. It shortens life expectancy to mid 40s, and can cause very painful and potentially lethal complications. However, with genetic engineering we could insert a functioning copy of the gene into a patient's bone marrow cells, and they would be able to produce normal blood cells. In a few months after all their defective sickle blood cells died off, they would be free of the disease. However, I think use of genetic engineering to change a human's appearance, intelligence, or behavior is too much.
AnswerThe universality of the genetic code means that all living organisms are descended from one original organism, which is at least useful information. From a religious point of view, it could also be said that the creator god designed a successful genetic code and chose to use it universally. So, the genetic code does not actually prove or disprove evolution versus religion. But it proves the Theory of Evolution to be the best scientific explanation ofr life on earth.
Point.
A point mutation changes one nitrogenous base in the genetic code, which can alter the amino acid sequence in a protein. This can lead to a different protein being produced, affecting the function of the protein and potentially causing genetic disorders.
Celiac disease is primarily associated with specific genetic variations in the HLA-DQ genes, particularly HLA-DQ2 and HLA-DQ8, rather than being caused by a point mutation or frameshift mutation. These variations are typically due to small insertions or deletions that can alter the amino acid sequence, but the disease is more strongly linked to these haplotypes than to a single mutation type. Therefore, while mutations can play a role in the genetic predisposition to celiac disease, it's not accurately characterized solely as a point or frameshift mutation.
A frameshift mutation is caused by adding one nucleotide into the middle of a sequence. This type of mutation alters the reading frame of the genetic code, leading to a completely different amino acid sequence downstream of the insertion point.
Yes, a point mutation can result in a frameshift mutation if it occurs in a coding region of a gene and disrupts the reading frame of the genetic code.
Phenylketonuria (PKU) is primarily caused by a genetic mutation in the PAH gene, which encodes the enzyme phenylalanine hydroxylase. This mutation is often a point mutation, which involves a single nucleotide change in the DNA sequence that can lead to a dysfunctional enzyme. However, PKU can also result from other types of mutations, including deletions or insertions, but point mutations are the most common cause.
SCID can be caused by a variety of genetic mutations, including both frameshift and point mutations. Frameshift mutations involve the insertion or deletion of nucleotides that shifts the reading frame of a gene, while point mutations involve the substitution of a single nucleotide.
A frameshift mutation, where an insertion or deletion of nucleotides causes a shift in the reading frame of the genetic code, can change every amino acid that follows the point of mutation. This can have dramatic effects on the resulting protein's structure and function.
A genetic mutation is a change in the DNA sequence that can affect an organism's traits. The types of genetic mutations include point mutations (substitution, insertion, deletion), frameshift mutations, and chromosomal mutations (deletion, duplication, inversion, translocation).
No, it's caused by a single point mutation of a gene.
A point mutation occurred in the DNA strand. This is a change in a single nucleotide base, such as a substitution, insertion, or deletion.
PKU (phenylketonuria) is a point mutation, specifically an autosomal recessive genetic disorder caused by a mutation in the PAH gene. This mutation leads to impaired metabolism of the amino acid phenylalanine. It is not a frameshift mutation, which would involve an insertion or deletion of nucleotides, shifting the reading frame of the gene.
Sickle cell anemia.