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You should be using Mobil 1 in your engine. With that, about 10,000 miles should be fine. And make sure to replace the oil filter as well...use OEM filters. From my experience, after market filters are no where close to OEM.

If you're not using Mobil 1, 3000 miles is recommended.

Also, depending on your mileage...you should check the other fluids, such as: Power Steering, brake fluid...check the color...if it's not clear, its time to flush the system. Also, most importantly, check the last time your trans was serviced. If its more than 40,000, change the oil and filter...this is considerably less mileage than MB suggests, but these new transmissions will last a lot longer with 40k services. Check the rear end fluid and if the fuel filter has more than 40k on it, change it.

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