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Cooking a 15-pound brisket typically takes about 1 to 1.5 hours per pound when using low and slow methods, such as smoking or slow roasting at around 225-250°F. This means the total cooking time can range from 15 to 22.5 hours. It's crucial to use a meat thermometer to check for doneness, aiming for an internal temperature of around 195-205°F for optimal tenderness. Resting the brisket for at least an hour after cooking is also recommended before slicing.

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