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The active ingredient in 'magic' mushrooms or 'shrooms' is a psycho-active substance called psilocybin. It occurs naturally when rye is subjected to alot of moisture which makes these fungi grow on the plant, they call this form 'argot'. It may also grow in cow feces or in a darker parts of a forest (under the right circumstances). This psilocybin was also synthesized in a lab in 1938 by Albert Hofman at the Sandoz Pharmaceutical lab in Switzerland. This form is known as L.S.D. or Lysergic Acid Diethylamide. L.S.D. unlike the rest of these substances can be absorbed through the skin. Argot and mushrooms can be handled more safely. Hofman found this out first hand, when he accidentally ingested 200 micrograms of it, through his pores on his hands. Needless to say he saw the medicinal effects and/or the psycho-active benefits. The Swiss government funded his research for the drug and many other counties were researching its effects in controlled settings. It was made illegal in the drug act of 1972.

Ergot or 'argot' does not contain psilocybin, nor was LSD synthesized from it. The main active ingredient in most magic mushrooms is psilocybin, although there is usually two other triptamine alkoids present as well, psilocin and baeocystin although psilocybin is metabolized into psilocin when ingested.

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