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Near the beginning of chapter 6, we find the following quote from Sherlock Holmes:

". . . I have made some inquiries myself in the last few days, but the results have, I fear, been negative. One thing only appears to be certain, and that is that Mr James Desmond, who is the next heir, is an elderly gentleman of a very amiable disposition, so that this persecution does not arise from him. I really think that we may eliminate him entirely from our calculations. . . ."

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