The Krebs cycle is the sequence of reactions by which most living cells generate energy during aerobic respiration. It takes place in the mitochondria, consuming oxygen, producing carbon dioxide and water as waste products, and converting ADP to energy-rich ATP.
oxygen
Since Krebs is a cycle, there is a pretty good argument that there is no "first metabolite". However, because citrate is a condensation product of OAA and acetyl-CoA, and acetyl-CoA is typically what is feeding in to the Krebs cycle, citrate could be considered the "first metabolite"
The Krebs Cycle generates 3 molecules of NADH with 3 H+ ions as well as one seperate molecule of FADH2. Both are shuttled to the electron transport chain in the inter-mitochondrial membrane. The NADH is oxidized as its electrons are moved through the first protein in the chain. Ubiquinone (the coolest name in all of biology) accepts the electrons from FADH2 also oxidizing it. At the end of the chain, the final protein passes the electrons (H+ ions) onto half of an O2 molecule forming one molecule of water.
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The two molecules of pyruvic acid (pyruvate) produced from glycolysis (glucose, glucose-6-phosphate, fructose-6-phosphate, fructose 1,6 biphosphate.... pyruvate) turn into acetyl coenzyme A (acetyl CoA). Acetyl CoA enters the Krebs cycle, reacting with oxaloacetate to form citrate [which is why the Krebs cycle is known as the citric acid cycle].
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Citrate
Since Krebs is a cycle, there is a pretty good argument that there is no "first metabolite". However, because citrate is a condensation product of OAA and acetyl-CoA, and acetyl-CoA is typically what is feeding in to the Krebs cycle, citrate could be considered the "first metabolite"
The first reactant and last product are the same.
The first reactant and last product are the same.
If by "first carbon" you mean the first CO2 released in the cycle then the answer is, from OAA. NOT from acetyl CoA.
ATP (Adenosine Triphosphate) ?
Citric Acid
First stage is Glycolysis pyruvate is then turned into Acetyl CoA and enters the Krebs Cycle Second stage is Krebs Cycle Third stage is Electron transport chain
The first reactant and last product are the same.
The first reactant and last product are the same.
Glycolysis evolved first. Cells of all types of organisms are able to carry out glycolysis. The Krebs cycle arose after photosynthetic organisms began adding oxygen to the atmosphere because Krebs cycle requires oxygen and glycolysis does not.
The first stage is the break down of glucose. The second stage is the Krebs Cycle which breaks down the pyruvic acid. The third stage is the electron transport system which occurs in O2 and in the mitochondria.