Since Krebs is a cycle, there is a pretty good argument that there is no "first metabolite". However, because citrate is a condensation product of OAA and acetyl-CoA, and acetyl-CoA is typically what is feeding in to the Krebs cycle, citrate could be considered the "first metabolite"
The Krebs cycle is the sequence of reactions by which most living cells generate energy during aerobic respiration. It takes place in the mitochondria, consuming oxygen, producing carbon dioxide and water as waste products, and converting ADP to energy-rich ATP.
The two molecules of pyruvic acid (pyruvate) produced from glycolysis (glucose, glucose-6-phosphate, fructose-6-phosphate, fructose 1,6 biphosphate.... pyruvate) turn into acetyl coenzyme A (acetyl CoA). Acetyl CoA enters the Krebs cycle, reacting with oxaloacetate to form citrate [which is why the Krebs cycle is known as the citric acid cycle].
The Krebs Cycle generates 3 molecules of NADH with 3 H+ ions as well as one seperate molecule of FADH2. Both are shuttled to the electron transport chain in the inter-mitochondrial membrane. The NADH is oxidized as its electrons are moved through the first protein in the chain. Ubiquinone (the coolest name in all of biology) accepts the electrons from FADH2 also oxidizing it. At the end of the chain, the final protein passes the electrons (H+ ions) onto half of an O2 molecule forming one molecule of water.
zygote
Interphase, which is the first stage in the cell cycle
Citrate
The first six-carbon molecule produced in the Krebs cycle is citrate, also known as citric acid. It is formed by condensation of acetyl-CoA and oxaloacetate catalyzed by the enzyme citrate synthase.
List of enzymes used in Krebs cycle are: 1. citrate. 2. isocitrate. 3.alpha- ketoglutarate. 4. succinyl- CoA. 5. succinate. 6. fumarate. 7.malate. 8.oxaloacetate. Hope this helps.
The conguate base of citric acid - citrate - is an important intermediate in the cycle. This is where the name "Citric Acid Cycle" comes from. It is also known as the Tricarboxylic Acid Cycle - as it involves 3 carbon acids, or the Krebs Cycle after Hans Adolf Krebs - who developed the complexities of the cycle.
The first step of the Krebs cycle involves the condensation of acetyl-CoA and oxaloacetate to form citrate, catalyzed by the enzyme citrate synthase. This reaction is irreversible and initiates the series of reactions that ultimately lead to the production of energy-rich molecules like ATP.
The compound produced by the transfer of the acetyl group of acetyl CoA to oxaloacetate is citrate, which is the first step in the citric acid cycle (Krebs cycle). This reaction is catalyzed by the enzyme citrate synthase.
A 6 carbon compound formed during the Krebs cycle is citrate. It is the first product formed in the cycle when acetyl-CoA combines with oxaloacetate.
Acetyl CoA must interact with oxaloacetate to form citrate in the first step of the Krebs Cycle.
It is true that the compound that joins with a 4-carbon molecule in the krebs cycle is called acetyl-CoA. It is also known as Acetyl coenzyme A.
The Krebs cycle is also known as the citric acid cycle because one of the critical intermediates in the cycle is citric acid, which is produced when acetyl-CoA combines with oxaloacetate. The cycle plays a central role in cellular respiration and occurs in the mitochondria of eukaryotic cells.
Oxaloacetate is a crucial component of the Krebs cycle as it combines with acetyl-CoA to form citrate, the first step in the cycle. It also regenerates at the end of the cycle to continue the process. Oxaloacetate plays a key role in the conversion of nutrients into energy in the form of ATP.
Citric acid is formed in the Krebs cycle when oxaloacetate, a four-carbon compound, combines with acetyl-CoA, a two-carbon compound derived from pyruvate. This condensation reaction is catalyzed by the enzyme citrate synthase, resulting in the formation of citric acid as the first intermediate in the cycle.