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As soon as someones mouth touches the bottle, bacteria is present. Allowed to sit for a couple of days, the water will "foul"...(develop an unfresh taste). Refridgeration helps delay this fouling process whilst direct sunlight and heat will hasten it. Bottles that have been LEFT OPEN for days or weeks may have additional contaminants introduced to them, and, if ingested may cause mild diarrhea. Keeping open bottles "cool" will cause no problems.

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