Yes.
The most common route is to take I-81 South to I-77 South, then merge onto I-26 East towards Charleston. From there, take I-95 South which will take you all the way to Fort Lauderdale. This route is approximately 1,300 miles and takes around 19-20 hours of driving time without factoring in stops.
385 miles taking this route:Take I-90 THRUWAY WEST from Utica to I-81 SOUTH via I-481 SOUTH (EXIT 34A off I-90 THRUWAY; follow signs to I-481 SOUTH).Take I-81 SOUTH to I-83 SOUTH to SOUTH HARRISBURG and YORK at EXIT 70 in PENNSYLVANIA.Take I-83 SOUTH to Baltimore.
885 miles taking this route:Take I-78 WEST, from New York, to I-81 SOUTH to HARRISBURG at EXIT 1A in PENNSYLVANIA.Take I-81 SOUTH down to I-40 WEST to KNOXVILLE at EXIT 0B.Take I-40 WEST to Nashville.
The drive from Newburgh, NY to Harrisburg, PA is approximately 4 hours, covering a distance of around 220 miles. You would typically take I-78 West to I-81 South for the most direct route. Make sure to account for traffic conditions and rest stops along the way.
78 miles taking this route:Take I-78 WEST to I-81 SOUTH to HARRISBURG.Take I-81 SOUTH to I-83 SOUTH to SOUTH HARRISBURG and YORK at EXIT 70.Take I-83 SOUTH to PA-581 WEST to CAMP HILL and GETTYSBURG at EXIT 41 A.Take PA-581 to Camp Hill.
Take I-84 WEST to I-81 SOUTH to WILKES-BARRE in Pennsylvania.Take I-81 SOUTH to I-83 SOUTH to SOUTH HARRISBURG and YORK at EXIT 70.Take I-83 SOUTH to Baltimore.
Take I-78 WEST (or U.S. 22 WEST to I-78 WEST) to I-81 SOUTH to HARRISBURG.Take I-81 SOUTH to Harrisburg.
250 miles taking this route:Take ROUTE 8 - SOUTH (towards BRIDGEPORT), from Derby, to I-95 SOUTH to NEW YORK CITY.Take I-95 SOUTH to I-287 WEST to TAPPAN ZEE BRIDGE at EXIT 21 in NEW YORK.Take I-287 WEST & SOUTH, around NYC, to I-78 WEST to ALLENTOWN at EXIT 21B in NEW JERSEY.Take I-78 WEST to I-81 SOUTH to HARRISBURG at EXIT 1A in PENNSYLVANIA.Take I-81 SOUTH to Harrisburg.
200 miles taking this route:Take I-81 SOUTH from Scranton to I-83 SOUTH to SOUTH HARRISBURG and YORK at EXIT 70 near Harrisburg.Take I-83 SOUTH to Baltimore.
Just take I-81 NORTH to Scranton.
Take I-81 SOUTH to I-83 SOUTH to SOUTH HARRISBURG and YORK at EXIT 70.Take I-83 SOUTH to I-695 WEST outside of Baltimore, MD.Stay on I-695 to I-95 SOUTH to WASHINGTON at EXIT 11A.Take I-95 SOUTH to Washington.
It is 131 miles taking I-81 SOUTH.
There is a Swatara Township in Dauphin county(near Harrisburg) and in Lebanon County (near the I-78/I-81 split)
628 miles taking this route:Take ROUTE 440 WEST from Perth Amboy to I-287 NORTH.Take I-287 NORTH to I-78 WEST to EASTON, PA at EXIT 21B.Take I-78 WEST to I-81 SOUTH to HARRISBURG at END I-78 in PENNSYLVANIA.Take I-81 SOUTH to I-77 SOUTH to CHARLOTTE, NC at EXIT 81 in VIRGINIA.Take I-77 SOUTH to Charlotte.
Take I-70 WEST, from Asheville, to I-81 SOUTH to ROANOKE at EXIT 26A, near Hagerstown.Take I-81 SOUTH down to I-26 EAST to ASHEVILLE at EXIT 57A in TENNESSEE.Take I-26 EAST to ASHEVILLE.This route is about 515 miles in length.
Take I-88 WEST to I-81 SOUTH to BINGHAMTON at END I-88.Take I-81 SOUTH to I-77 SOUTH CHARLOTTE, NC at EXIT 81 in Virginia.Take I-77 SOUTH to Charlotte.
490 miles taking this route:Take I-81 SOUTH to I-83 SOUTH to SOUTH HARRISBURG and YORK at EXIT 70 in Pennsylvania.Follow I-83 SOUTH through Pennsylvania to I-695 WEST to PIKESVILLE and WASHINGTON near Baltimore, MARYLAND.Stay on I-695 around Baltimore to I-95 SOUTH to WASHINGTON at EXIT 11A.Take I-95 SOUTH to Richmond.