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Tissue transglutaminase antibody (tTG-IgA) is an autoantibody commonly associated with celiac disease, an autoimmune disorder triggered by gluten consumption. It targets the enzyme tissue transglutaminase, which plays a role in the modification of gluten peptides. Elevated levels of tTG-IgA are often used as a biomarker for diagnosing celiac disease, and testing for these antibodies is a standard part of the diagnostic process. A positive result typically indicates an immune reaction to gluten, leading to intestinal damage.

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6d ago

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What does high transglutaminase mean?

Antibodies against tissue transglutamase is a sign of Celiac disease, also known as gluten intolerance.


How do you read a TTG IgA lab test?

A TTG IgA lab test measures the levels of tissue transglutaminase antibodies in the blood, which are often elevated in individuals with celiac disease. A positive result typically indicates a higher likelihood of celiac disease, particularly when accompanied by symptoms or other diagnostic findings. However, it's important to interpret the results in conjunction with clinical symptoms and potentially other tests, as false positives can occur. Always consult with a healthcare provider for accurate diagnosis and interpretation.


What is the chemical formula for transglutaminase?

Eight transglutaminases are known today.


What and how is a celiac test done?

A Celiac disease test involves finding out if the small intestine is sensitive to gluten, and such tests include the endomysial antibody (EMA) test and the tissue transglutaminase antibody test.


Does transglutaminase negative 4.6 means that you have celiac disease?

A transglutaminase antibody test result of negative (4.6) typically indicates that you are unlikely to have celiac disease, as positive results usually suggest an immune response associated with the condition. However, diagnosis of celiac disease involves more than just antibody tests; it may require additional testing and a biopsy of the small intestine. It's important to consult a healthcare professional for an accurate diagnosis and interpretation of test results.


What does the medical abbreviation IgA mean?

IgA stands for immunoglobulin A.


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