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Yes, especially if taken with OTC painkillers such as aspirin, ibuprofen and naproxen sodium, or preparations that contain them. Chronic alcohol use can affect the body's ability to clot due to liver damage. In addition, one complication of cirrhosis is esophageal varices, or varicose veins in the esophagus. If these begin to bleed, there can be catastrophic consequences.

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