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Yes, but only with medical support. Individuals who have the large intestine removed, or with an intestinal bypass, may have their ileum directly connected to the colon or rectum, and will not utilize the large intestine (an ileostomy is often used as an intermediate step). Since absorption of nutrients takes place in the small intestine, this allows continued metabolism. However, this condition can lead to dehydration due to lack of water absoption, and deficiencies of some vitamins that are taken in through the large intestine.

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