Yes, it's possible to die of laughter, as in 1975, Alex Mitchell, who watched the television program, "Kung Fu Kapers" (episode: The Goodies), laughed for 25 straight minutes and then died of heart failure and exhaustion.
There are other reports of people dying from laughter. For example:
No, you don't lose cells that's a myth
no you don't lose brain cells you fool
you lose brain cells
no but you will lose brain cells
On average, you do not lose brain cells each day. The brain has the ability to regenerate and repair itself, so the number of brain cells remains relatively stable over time.
sniff gasoline
Brain cells
yes
yes it does
No.
In fact hot Cheetos do not make you lose brain cells they increase your brain cell activity so you are more awake and able to concentrate -Dr.Justin
Yes you do because when you hit someone your brain cells get killed because your brain cells are very easy to damage!