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Tamiflu is an antiviral medication that is most effective when taken within 40 hours of the first symptoms to prevent a virus from reproducing. This prevention of the virus's reproduction is accomplished by inhibiting the action of a protein that would otherwise enable the release of new virus particles from the infected person's cells, in which they have developed. Tamiflu is most effective as a treatment, instead of for prophylaxis (prevention of infection).

It does not actually stop the virus from invading your cells in the first place. But it can make your symptoms less severe, and it will make the duration of the viral infection shorter. If started within one day, or under 40 hours at the latest, of the first symptoms, it may even make the symptoms very minor or negligible in some people. This treatment to reduce the severity of symptoms and their duration is the most common reason for prescription of the drug. It is one of the two antiviral drugs that are effective in the treatment of the "Novel" A-H1N1/09 strain of influenza.

It is approved also for use as a prophylactic for people over one year old, when there is known virus in a household or community. If the timing is just right to stop the release of the virus particles that are made from the first cells to be infected by the virus, it can help avoid any flu symptoms and control the reproduction of the virus so that only the minimum number of cells will be invaded. This is how it can be used as a prophylactic aid.

According to the indications and efficacy statements in the Tamiflu patient information,

"In a pooled analysis of two seasonal prophylaxis studies in healthy unvaccinated adults (aged 13 to 65 years), TAMIFLU 75 mg once daily taken for 42 days during a community outbreak reduced the incidence of laboratory-confirmed clinical influenza from 4.8% (25/519) for the placebo group to 1.2% (6/520) for the TAMIFLU group."

The typical incidence rate of A-H1N1/09 in communities where it has been tracked was around 6% without treatment.

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15y ago

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