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Yes. There are medical conditions which cause depression. The most common conditions are 1) hypothyroidism, 2) significant anemia, 3) chronic pain disorders, 4) headaches, 5) Heart disease, 6) many cancers, 7) neurological disorders, especially Parkinson's Disease; and many more.

Tests which are helpful in screening for potential medical causes of depression, such as those above, include thyroid testing (free T4, TSH), and PBC (to check hemoglobin levels which, if low, should prompt iron, B12 and folic acid level studies).

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