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According to researchers in Sweden, people with rheumatoid arthritis are roughly twice as likely as those without the disease to develop lymphoma, which is a broad term for a variety of cancers of the lymphatic system. The researchers conducted the largest investigation of the link between RA and lymphoma to date.
Their findings, featured in the March 2006 issue of Arthritis & Rheumatism indicate a substantially increased risk of lymphoma among patients with severe RA. Very high and prolonged inflammatory activity, not its treatment, is apparently the major risk factor.
The research team analyzed the medical records and case histories of 378 RA patients afflicted with malignant lymphoma between 1964 and 1995 and 378 individually matched, lymphoma-free controls. Using statistical analysis, the relative risks or odds ratios for lymphoma were assessed for three different levels of overall disease activity-low, medium, or high-based on disease duration and swollen and tender joint counts.
Compared with low RA activity, medium RA activity was associated with an 8-fold increase in the risk for lymphoma. The odds ratio rose dramatically for high RA activity-to a 70-fold increase in lymphoma risk. The researchers also observed increased risks of lymphoma associated with pronounced, irreversible joint damage in the hands, feet, and knees documented in the last year before lymphoma diagnosis.
What else can I help you with?
What is Sideroblastic anemia associated with?
Sideroblastic anemia is also associated with: leukemia, lymphoma (cancer of the lymph glands), myeloma (cancer of the bone marrow), rheumatoid arthritis, and other inflammatory diseases
Can cognitive-behavioral therapy treat chronic pain?
It is also frequently used as a tool to deal with chronic pain for patients with illnesses such as rheumatoid arthritis, back problems, and cancer.
Could finger pain be a sign of cancer?
Finger pain is probably not a sign of cancer, but if there is ongoing pain in your finger I do suggest that you get it checked out. It could be a sign of Rheumatoid Arthritis.
What diseases and disorders can effect ligaments?
Ligaments can be torn or broken due to injury or fracture, and they can get inflamed in rheumatoid arthritis and infected in septic arthritis
What ailments can be treated by urine therapy?
Multiple sclerosis , colitis, lupus, rheumatoid arthritis, cancer, hepatitis , hyperactivity, psoriasis, eczema , diabetes, herpes, mononucleosis , and adrenal failure.
What characteristics does an abnormal ESR test have?
The highest ESR levels are usually seen in a cancer of a certain type of white blood cell (multiple myeloma ) and rheumatoid disease, such as rheumatoid arthritis. Many other diseases also increase the ESR: infection, kidney.
Is chemotherapy used for treatment other than cancer?
Yes. Methotrexate is now being used as a treatment (low dosage) for some autoimmune diseases, including ankylosing spondylitis, Crohn's disease, psoriasis, psoriatic arthritis, rheumatoid arthritis, and scleroderma.
Expression of interlukin-6 in rheumatoid arthritis?
IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, systemic lupus erythematosus, prostate cancer, and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases. The first such is tocilizumab which has been approved for rheumatoid arthritis. Another, ALD518, is in clinical trials.Tocilizumab (INN, or atlizumab, developed by Hoffmann-La Roche and Chugai under the trade names Actemra and RoActemra) is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R) used as an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis. Interleukin 6 is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.(Source wikipedia)
What medical conditions result in fluid build up around the heart?
Excess fluid build up is often associated with pericarditis, which is an inflammation of the pericardium.Other causes are cancer, injury to the pericardium or heart from a medical procedure, heart attack. severe kidney failure, lupus, rheumatoid arthritis and bacterial infections.
What causes high Platelet count?
Having a high platelet count is called thrombocytosis. This can be caused by cancer, anemia, rheumatoid arthritis, tuberculosis, and use of birth control pills.
What are omega-6 fatty acids used for?
EFAs protect against such conditions as heart disease; cancer; autoimmune diseases, including rheumatoid arthritis and multiple sclerosis; skin diseases, including acne, atopic eczema, and psoriasis
What has the author Richard Alan Sobel written?
Richard Alan Sobel has written: 'Role of emotional expression, selected personality factors, and early childhood experience in the development of cancer, rheumatoid arthritis, coronary heart disease, and health'
