blood coagulation factors.
1 fibronogen
11 prothrombin
111 tissue thromboplastin
1v calcium
v labile factor
v1 combined with factor v
v11 stable factor
v111 antihaemophilic factor
1x Christmas factor
x stuart factor
x1 plasma thromboplastin antecedent
x11 hageman factor
x111 fibrin stablizing factor
Extrinsic
The activated partial thromboplastin time (aPTT) test measures the intrinsic pathway of coagulation. It assesses the function of various clotting factors, including factors VIII, IX, XI, and XII, by evaluating the time it takes for blood to clot after the addition of an activator and phospholipids. Prolonged aPTT can indicate deficiencies or inhibitors in the intrinsic pathway.
The extrinsic coagulation system is one of the two initial pathways in the blood coagulation process that is activated by external trauma or injury. It involves factors released from damaged blood vessels and tissues to initiate clot formation. This pathway ultimately converges with the intrinsic pathway to form a stable blood clot.
Blood coagulation can occur either through an intrinsic or extrinsic pathway. The first step in either pathway begins with the production of Factor X,which marks the common pathway of coagulation.
Prothrombin time (PT) measures the activity of coagulation factors in the tissue factor pathway of the coagulation cascade.
extrinsic pathway of coagulation the mechanism that produces fibrin following tissue injury, beginning with formation of an activated complex between tissue factor and factor VII and leading to activation of factor X, inducing the reactions of the common pathway of coagulation.intrinsic pathway of coagulation a sequence of reactions leading to fibrin formation, beginning with the contact activation of factor XII, and resulting in the activation of factor X to initiate the common pathway of coagulation.
The prothrombin time (PT) test measures how long it takes for blood to clot. This test evaluates the coagulation factors involved in the extrinsic pathway.
The intrinsic pathway of blood coagulation is initiated within the bloodstream by damage to the blood vessel, while the extrinsic pathway is initiated outside the bloodstream by tissue factor released from damaged tissues. Both pathways ultimately converge to activate factor X and lead to the formation of a blood clot.
Factor VIII is crucial in the intrinsic pathway of the blood coagulation system. It helps in the activation of factor X, which is a key step in the formation of a blood clot. Without factor VIII, this pathway would be impaired, leading to difficulties in clot formation.
An important difference between the extrinsic and intrinsic blood clotting pathways is the way they are initiated. The extrinsic pathway is activated by external trauma that exposes tissue factor, while the intrinsic pathway is triggered by factors within the bloodstream, such as collagen or platelets. Additionally, the extrinsic pathway is faster and primarily involved in the initial response to injury, while the intrinsic pathway is more complex and amplifies the clotting process.
Thromboplastin, also known as tissue factor, is released from damaged tissues or activated platelets during blood vessel injury. It initiates the extrinsic pathway of the coagulation cascade by forming a complex with coagulation factor VII, triggering the cascade that ultimately leads to the formation of a blood clot.
Thromboplastin, also known as tissue factor, is released from damaged tissues and activated endothelial cells in response to injury. When blood vessels are damaged, the exposure of collagen and other underlying structures triggers the release of thromboplastin into the bloodstream. This protein then interacts with factor VII to initiate the extrinsic pathway of coagulation, ultimately leading to the formation of a blood clot.