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If sickle-cell anemia is so destructive why hasn't the sickle-cell allele been eliminated from the population?
It is important to note that sickle-cell anemia comes in two forms. The homozygous sickle-cell anemia and the heterozygous sickle-cell trait. The difference between the two is that sickle-cell anemia has a high rate death rate at a young age (20~), and the sickle-cell trait is nearly asymptomatic.In regions such as North America, sickle-cell anemia would be selected against and would eventually leave the gene pool. The sickle-cell trait on the other hand, has little effect on the fitness of the organism, and as such will remain in the gene pool.In malaria endemic regions such as sub-Sahara Africa, sickle-cell anemia provides very high levels of immunity to malaria and the sickle-cell trait provides a slightly lesser level of immunity. Both forms of sickle-cell will increase the organisms fitness and as such, it will remain in the gene pool. Further on, the sickle-cell trait has greater fitness than sickle-cell anemia, hence, the sickle-cell trait will be selected as the fittest allele.If s is the sickle-cell allele and S is a normal allele;The relative fitness in malaria endemic regions;Ss > ss > SSSickle-cell trait > Sickle-cell anemia > NormalThe relative fitness in non-malaria endemic regions;SS > Ss > ssNormal > Sickle-cell trait > Sickle-cell anemia
High white blood cell count is called?
Sickle cell
How does a person with one sickle cell different than two Sickle cell?
A person with one sickle cell is a "carrier". This means that they have the dormant cell in their genetic composition, and if combined with another with the "carrier" gene, they run the high risk on concieving a child with the blood disease-one who has two sickle cells. A person with two sickle cells, has the sickle cell disease and are carriers(The gene is not dormant but active). Hope this simplifies and explains it for you.
Can sickle cell cause high white blood cells?
Yes in sickl cell disease the white blood cell is
Why do the attacks of sickle cell crisis increase in high altitude?
The main reason that attacks of sickle cell crisis increase in high altitudes is oxygen. When the body lacks or needs more oxygen, it makes the body work more to get it, thus causing the crisis. http://www.nytimes.com/health/guides/disease/sickle-cell-anemia/print.html
What NFL player is unable to play at denver because of the Pressure?
Safety Ryan Clark. He had to have his spleen removed after his sickle cell disease was aggravated playing at high elevation in Denver in 2007.
How many African American are carriers of the sickle cell?
A very high ratio of 1 in 11.
How many African Americans are carriers of the sickle-cell?
A very high ratio of 1 in 11.
How many Africans are carriers of the sickle cell allele?
A very high ratio of 1 in 11.
How many African Americans are carriers of sickle-cell allele?
A very high ratio of 1 in 11.
The mutant allele causing sickle-cell anemia is found at high frequency mainly due to?
Sickle cell anemia is found in high frequency because it is a codominant mutation. It only requires one allele for the gene to manifest.
Does the environment play a role in sickle cell anemia?
Yes, the environment can play a role in sickle cell anemia by affecting factors such as hydration, temperature, and altitude that can trigger sickling of red blood cells and potentially lead to complications. Staying well-hydrated, avoiding extreme temperatures, and adjusting to high altitudes can help manage symptoms and reduce the risk of sickle cell crises in affected individuals.
