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Endochondral ossification is a complex process where cartilage is transformed into bone, crucial for the development of long bones. It begins with the formation of a cartilage model, which is then replaced by bone through a series of well-coordinated stages, including chondrocyte proliferation, hypertrophy, and the invasion of blood vessels. This process is tightly regulated by various signaling pathways and hormones, such as Indian hedgehog (Ihh) and parathyroid hormone-related peptide (PTHrP), ensuring proper timing and spatial organization. Disruptions in this regulation can lead to skeletal abnormalities and growth disorders.

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