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Sickle cell disease causes red blood cells to become rigid and crescent-shaped, which can obstruct blood flow in small vessels. This blockage can lead to decreased oxygen delivery and tissue damage, promoting inflammation and increasing the risk of blood clot formation. Additionally, the altered shape of sickle cells can trigger the activation of the coagulation cascade, further contributing to clot development. As a result, individuals with sickle cell disease are at an elevated risk for vaso-occlusive crises and thrombotic events.

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1mo ago

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Sickle Cell disease A disease that involves misshaped cells that can easily cause blood clots.


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Both were carriers.


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Although sickle cell anemia(SS) and sickle cell disease(SC) are considered genetic mutations, I believe the question is...What are possible causes for a sickle cell attack? Anything that causes a constriction of the blood vessels would seem to be a cause. Smoking, coffee, and alcohol to name a few. Dehydration also appears to play a big role.