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What diseases arises from an amino acid change in protein hemoglobin?
sickle cell disease
Can you Describe how the amino acids changes in the protein affect the function of the protein and how this causes disease?
Changes in amino acids can alter the protein's structure, affecting its function by disrupting its binding sites or enzyme activity, leading to disease. For example, in sickle cell anemia, a single amino acid change in hemoglobin causes it to form abnormal-shaped red blood cells, affecting oxygen transport and leading to the disease's symptoms.
What genetic disease may be caused by a change or mutation in the hemoglobin gene?
sickle-cell anemia.
A change in one nucleotide produces a different form of hemoglobin in some people. Which conditions result from this change?
Sickle cell disease
A change in one nucleotide produced a different form of hemoglobin in some people. which condition results from this change?
Sickle cell disease
what change in one nucleotide produces a different form of hemoglobin in some people which condition results from this change?
Sickle cell disease
How does sickle cell hemoglobin differ from normal hemoglobin?
Sickle cell hemoglobin differs from normal hemoglobin due to a mutation in the gene that codes for the hemoglobin protein. This mutation leads to the production of an abnormal hemoglobin variant (HbS) that causes red blood cells to become sickle-shaped, leading to various complications such as blockages in blood vessels and reduced oxygen delivery to tissues.
What common genetic variation which causes a change in the amino acid sequence in the structure of hemoglobin leads to what disease?
Sickle cell
What is glutamate replaced by in sickle cell anemia?
In sickle cell anemia, glutamic acid is replaced by valine due to a single base change in the gene that codes for hemoglobin. This substitution causes the hemoglobin protein to form abnormal sickle-shaped red blood cells, leading to the symptoms of the disease.
What cause sickle-cell disease?
It's caused by a mutation in the hemoglobin gene (a weird change that's basically in the red blood cell).It has to come from two parents who both have a trait of sickle cell. Not all of their kids will have it though. Some kids might have the trait, while some will actually have sickle cell anemia, and some might have no trait of it at all. It's a strange, strange mutation.Sickle cell disease is caused by a point mutation in the gene that codes for hemoglobin which is the primary protein found in the red blood cells. Basically, in the sequence of that gene, one letter changes and causes the entire structure of the hemoglobin molecule to change. The affinity of oxygen to hemoglobin decreases so the mutated red blood cell ends up carrying less oxygen compared to a normal red blood cell.Due to this change, the red blood cell looks like a sickle so its is called a Sickle Cell Disease.
What change occurs in hemoglobin upon respiration?
The iron molecule (that's the hemo- in hemoglobin) gains and/or loses an oxygen molecule. The protein part (that's the globin) changes shape a bit. Both changes are very reversible and requires little energy.
How does changing a nucleotide in the DNA code for b-globin change the characteristics of hemoglobin?
Due to change in nucleotide, a completely different protein is coded for. The normal protein has glutamic acid, is hydrophillic; however, the mutated protein incorporates valine, a hydrophobic amino acid instead. This causes the overall haemoglobin protein to distort into a sickle shape, rather than a concave shape. As a result, sickle cells have a much shorter lifespan than their normal counterparts.
