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How does changing a nucleotide in the DNA code for b-globin change the characteristics of hemoglobin?

Updated: 8/9/2023

Wiki User

∙ 12y ago

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Due to change in nucleotide, a completely different protein is coded for. The normal protein has glutamic acid, is hydrophillic; however, the mutated protein incorporates valine, a hydrophobic amino acid instead.

This causes the overall haemoglobin protein to distort into a sickle shape, rather than a concave shape. As a result, sickle cells have a much shorter lifespan than their normal counterparts.

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∙ 12y ago

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