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Sickle cell hemoglobin differs from normal hemoglobin primarily due to a single amino acid substitution in the hemoglobin protein chain. In sickle cell disease, a person inherits two copies of an abnormal hemoglobin gene, usually referred to as HbS.

In normal hemoglobin (HbA), the amino acid glutamic acid is present at a specific position in the beta chain of the hemoglobin protein. However, in sickle cell hemoglobin (HbS), this glutamic acid is replaced by valine due to a genetic mutation. This change causes the hemoglobin molecules to stick together under certain conditions, forming long, rigid structures that distort red blood cells into a sickle or crescent shape.

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Saadia Khalid

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1y ago

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In which hereditary disease does abnormal hemoglobin differ from normal hemoglobin by only a single amino acid?

Sickle-cell anemia


What are the pros for SICKLE CELL ANEMIA?

The pro of sickle cell hemoglobin is that if you have only one allele for sickle cell hemoglobin and the other allele is normal, then you are immune to malaria.


What protein is not normal in people with sickle- cell disease?

Hemoglobin


What is the normal Hemoglobin level in Sickle Cell disease?

8


What protein is not normal in people with sickle-cell disease?

It is Hemoglobin


How is sickle cell hemoglobin differs from normal hemoglobin?

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What is the name of the condition of one sickle cell gene and one normal hemoglobin gene?

The condition is called sickle cell trait. This occurs when an individual inherits one sickle cell gene and one normal hemoglobin gene, resulting in milder symptoms compared to sickle cell disease.


Why does sickle cell hemoglobin migrate slower than normal hemoglobin during electrophoresis?

because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge


What are the different types of sickle cell disease and how do they differ from each other?

There are several types of sickle cell disease, including sickle cell anemia, sickle beta thalassemia, and sickle cell-hemoglobin C disease. These types differ based on the specific genetic mutations that affect the hemoglobin protein in red blood cells. Sickle cell anemia is the most common and severe form, where individuals have two copies of the sickle cell gene. Sickle beta thalassemia and sickle cell-hemoglobin C disease are milder forms that result from different combinations of genetic mutations. Symptoms and complications can vary among the different types of sickle cell disease.


Why does sickle cell hemoglobin migrate slower than normal hemoglobin during gel electrophoresis?

because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge


How does disease affect the cell?

Sickle cell disease is a mutation in the gene that codes for hemoglobin, which causes the hemoglobin and the cell to become elongated and look like a sickle rather than its normal disc shape.


What is the genotype of a man who has sickle cell trait?

rr since sickle cell is a recessive trait.