People who are heterozygous for sickle cell disease possess one normal hemoglobin gene and one sickle hemoglobin gene, which allows them to produce enough normal red blood cells to prevent symptoms of the disease. This condition, known as sickle cell trait, provides some protection against malaria, as the presence of sickle hemoglobin can interfere with the parasite's life cycle within red blood cells.
A person with one sickle cell gene and one normal hemoglobin gene has sickle cell trait, which can provide some protection against malaria. This advantage makes them more capable of surviving in regions where malaria is prevalent compared to someone with no sickle cell genes, who would be more susceptible to severe malaria infection.
Sickle cell hemoglobin differs from normal hemoglobin due to a mutation in the gene that codes for the hemoglobin protein. This mutation leads to the production of an abnormal hemoglobin variant (HbS) that causes red blood cells to become sickle-shaped, leading to various complications such as blockages in blood vessels and reduced oxygen delivery to tissues.
rr since sickle cell is a recessive trait.
Hemoglobin SS disease (Hb SS)
The pro of sickle cell hemoglobin is that if you have only one allele for sickle cell hemoglobin and the other allele is normal, then you are immune to malaria.
Hemoglobin
It is Hemoglobin
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People who are heterozygous for sickle cell disease possess one normal hemoglobin gene and one sickle hemoglobin gene, which allows them to produce enough normal red blood cells to prevent symptoms of the disease. This condition, known as sickle cell trait, provides some protection against malaria, as the presence of sickle hemoglobin can interfere with the parasite's life cycle within red blood cells.
because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge
because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge
Sickle cell disease is a mutation in the gene that codes for hemoglobin, which causes the hemoglobin and the cell to become elongated and look like a sickle rather than its normal disc shape.
A person with one sickle cell gene and one normal hemoglobin gene has sickle cell trait, which can provide some protection against malaria. This advantage makes them more capable of surviving in regions where malaria is prevalent compared to someone with no sickle cell genes, who would be more susceptible to severe malaria infection.
Sickle cell hemoglobin differs from normal hemoglobin due to a mutation in the gene that codes for the hemoglobin protein. This mutation leads to the production of an abnormal hemoglobin variant (HbS) that causes red blood cells to become sickle-shaped, leading to various complications such as blockages in blood vessels and reduced oxygen delivery to tissues.
rr since sickle cell is a recessive trait.