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How does sickle cell hemoglobin differ from normal hemoglobin?
Sickle cell hemoglobin differs from normal hemoglobin due to a mutation in the gene that codes for the hemoglobin protein. This mutation leads to the production of an abnormal hemoglobin variant (HbS) that causes red blood cells to become sickle-shaped, leading to various complications such as blockages in blood vessels and reduced oxygen delivery to tissues.
What are the pros for SICKLE CELL ANEMIA?
The pro of sickle cell hemoglobin is that if you have only one allele for sickle cell hemoglobin and the other allele is normal, then you are immune to malaria.
What protein is not normal in people with sickle- cell disease?
Hemoglobin
What is the normal Hemoglobin level in Sickle Cell disease?
8
What protein is not normal in people with sickle-cell disease?
It is Hemoglobin
What is the name of the condition of one sickle cell gene and one normal hemoglobin gene?
The condition is called sickle cell trait. This occurs when an individual inherits one sickle cell gene and one normal hemoglobin gene, resulting in milder symptoms compared to sickle cell disease.
Why does sickle cell hemoglobin migrate slower than normal hemoglobin during electrophoresis?
because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge
Why does sickle cell hemoglobin migrate slower than normal hemoglobin during gel electrophoresis?
because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge
How does disease affect the cell?
Sickle cell disease is a mutation in the gene that codes for hemoglobin, which causes the hemoglobin and the cell to become elongated and look like a sickle rather than its normal disc shape.
In which hereditary disease does abnormal hemoglobin differ from normal hemoglobin by only a single amino acid?
Sickle-cell anemia
What is the genotype of a man who has sickle cell trait?
rr since sickle cell is a recessive trait.
What is the difference between normal and sickle cell hemoglobin?
loss of only one amino acid from the normal hemoglobin molecule
