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loss of only one amino acid from the normal hemoglobin molecule

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What is the difference between normal and sickle-cell hemoglobin based on?

terminal amino acid of the beta chain


What is the molecular basis for the difference in the electrophoretic pattern between normal hemoglobin A and hemoglobin S?

The difference in electrophoretic pattern between normal hemoglobin A and hemoglobin S is due to a single amino acid substitution. In hemoglobin S, a glutamic acid is replaced by a valine at position 6 of the beta-globin chain. This change causes hemoglobin S to have a different charge, leading to its characteristic migration pattern on electrophoresis.


What are the pros for SICKLE CELL ANEMIA?

The pro of sickle cell hemoglobin is that if you have only one allele for sickle cell hemoglobin and the other allele is normal, then you are immune to malaria.


How does sickle cell hemoglobin differ from normal hemoglobin?

Sickle cell hemoglobin differs from normal hemoglobin due to a mutation in the gene that codes for the hemoglobin protein. This mutation leads to the production of an abnormal hemoglobin variant (HbS) that causes red blood cells to become sickle-shaped, leading to various complications such as blockages in blood vessels and reduced oxygen delivery to tissues.


What protein is not normal in people with sickle- cell disease?

Hemoglobin


What protein is not normal in people with sickle-cell disease?

It is Hemoglobin


What is the normal Hemoglobin level in Sickle Cell disease?

8


How is sickle cell hemoglobin differs from normal hemoglobin?

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How is sickle cell hemoglobin different from normal hemoglobin?

The difference is that a patient with sickle cell disease has an increased level of one specific type of Hemoglobin, that is Fetal hemoglobin or HbF. However, the amount of total hemoglobin is the same.


What is the name of the condition of one sickle cell gene and one normal hemoglobin gene?

The condition is called sickle cell trait. This occurs when an individual inherits one sickle cell gene and one normal hemoglobin gene, resulting in milder symptoms compared to sickle cell disease.


In which hereditary disease does abnormal hemoglobin differ from normal hemoglobin by only a single amino acid?

Sickle-cell anemia


Difference between thalassemia and sickle cell anemia?

Thalassemia is a genetic disorder as a result of an imbalance in the hemoglobin. In sickle cell, also a genetic disorder, the mutation cause a crescent shaped molecule.