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The Black Death was caused by bacteria carried by rats and their fleas. It spread quickly because rats lived in ships that traveled from one port to the next, and so the plague was carried across Europe in that way. Inland communications were often carried on by ships on rivers, so the plague spread up rivers quickly, as well.

The plague spread more slowly in areas without sea or river traffic. There were a very few places it did not reach at all. But most places in Europe are not far from water ports of one kind or another.

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