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Beta thalassemia is a genetic blood disorder that affects the body's ability to produce hemoglobin, the protein in red blood cells that carries oxygen. This leads to anemia, causing symptoms such as fatigue, weakness, and pale skin. The body may also respond by increasing iron absorption, which can lead to iron overload and damage to organs like the heart and liver if not managed properly. Additionally, individuals with beta thalassemia may experience bone deformities and growth delays due to the chronic shortage of healthy red blood cells.
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What chromosome is thalassemia carried on?
Thalassemia is carried on chromosome 11 and chromosome 16, depending on the type. The alpha-thalassemia gene is located on chromosome 16, while the beta-thalassemia gene is found on chromosome 11. Mutations in these genes affect the production of hemoglobin, leading to the various forms of thalassemia.
Can mild thalassemia be a major thalassemia?
No. A minor form of the blood disorder thalassemia is when you inherited just one beta thalassemia gene, along with a normal beta-chain gene. This manifests as mild anaemia with a slight lowering of the hemoglobin level in the blood. No treatment is require. By contrast, a thalassemia major, also known as Cooley's Disease, is when one is born with two genes for beta thalassemia and no normal beta-chain gene. This is a serious disorder.
Are there other names for Thalassemia disease?
Alpha thalassemia silent carrierAlpha thalassemia minor, also called alpha thalassemia traitHemoglobin H diseaseAlpha thalassemia major, also called hydrops fetalisBeta thalassemia minor, also called beta thalassemia traitBeta thalassemia intermediaBeta thalassemia major, also called Cooley's anemia or beta-zero (ß0) thalassemiaBeta-plus (ß+) thalassemiaMediterranean anemia
What is Hb Hope?
Beta thalassemia variant
What is classification of Thalassemia?
Thalassemia is classified mainly into two types: alpha thalassemia and beta thalassemia, based on which globin chain is affected. Alpha thalassemia occurs due to mutations in the alpha-globin genes, while beta thalassemia results from mutations in the beta-globin genes. Each type can further be categorized into various subtypes based on the severity of the condition, such as thalassemia minor (trait) and thalassemia major (Cooley's anemia). The classification helps determine the appropriate management and treatment strategies for affected individuals.
Will the child be free from thalassemia if you are alpha and father is beta thalassemia trait?
have seen one of my friends sister had kid and all normal no complications...not thalassemia either.........beta and alpha i think there is 25% normal chance
You are a black female with beta thalassemia minor trait both of your children have this trait can sickle cell anemia trait partner effect their children also?
If you have beta thalassemia trait and your partner has sickle cell trait there is a 25% chance of your child having sickle beta thalassemia.
Can minor thalassemia carrier and alpha marry?
Yes, A "carrier" of alpha thalassemia and of beta thalassemia can marry, but not to someone with any hemoglobinopathy. Prof. Kornfeld Pal
In child of age 2 which type of thalassemia occur?
In a child of age 2, the most common type of thalassemia that can occur is beta-thalassemia. This condition is characterized by reduced production of hemoglobin due to mutations in the beta-globin genes. Children with beta-thalassemia often present with symptoms such as anemia, fatigue, and delayed growth. Early diagnosis and management are crucial for improving outcomes.
What mutations does beta-thalassemia have on DNA?
Beta-thalassemia is typically caused by mutations in the HBB gene located on chromosome 11. Common mutations include point mutations, deletions, or insertions in the HBB gene, leading to reduced or absent production of beta-globin chains in hemoglobin. These mutations disrupt the normal structure and function of hemoglobin, resulting in anemia and other symptoms associated with beta-thalassemia.
What does the term thalassemia minor refer to?
If untreated, beta thalassemia major can lead to severe lethargy, paleness, and delays in growth and development. The body attempts to compensate by producing more blood, which is made inside the bones in the marrow.
How long do the beta thalassemia minor patient live?
5 to 10 years
