How does blocking the activity of acetylcholinesterase affect skeletal muscle?

Answer 1

Acetylcholine release is necessary for skeletal muscle contraction, because it serves as the first step in the process, enabling the subsequent cross-bridge formation. A muscle's ability to contract depends on the formation of cross-bridges between myosin & actin filaments. A drug that blocks acetylcholine release would interfere with this cross-bridge formation and prevent muscle contraction

Answer 2

Answer this questWhen the motor neuron releases acetylcholine into the neuromuscular junction, the acetylcholine binds to receptors in the muscle fiber that allows positively charged ions to enter the muscle fiber, which results in the muscle fiber contracting.

Answer 3

The skeletal muscle would not be able to relax. Therefore, it would stay contracted, resulting is a muscle spasm.