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What results from the hereditary lack of intrinsic factor?
Pernicious anemia (vitamin B 12 deficiency)
Inadequate intrinsic factor is associated with?
Inadequate intrinsic factor is associated with vitamin B12 deficiency, as intrinsic factor is necessary for the absorption of this essential nutrient in the gut. Vitamin B12 deficiency can lead to symptoms such as anemia, fatigue, and neurological problems. It is commonly seen in individuals with pernicious anemia or autoimmune conditions affecting the stomach lining.
Why do you need intrinsic factor?
Intrinsic factor or gastric intrinsic factor is a protein produced by the stomach. It is used to absorb vitamin B12 in the small intestine. When there is a deficiency of the Intrinsic factor, there is a deficiency in the absorption of B12 into the body and this leads to pernicious anemia.
How pernicious anemia cause achlorhydria?
pernicious anemia is a vitamin B12 deficiency. Vitamin B12 requires Intrinsic Factor to be reabsorbed by the ileum. Intrinsic Factor is produced by parietal cells in stomach. If there is some damage or manipulation of parietal cells, which also produce HCl, there will be less of both intrinsic factor causing B12 deficiency and HCl causing achlorhydria.
Why oral administration of vitamin B12 not effective as a treatment of pernicious anemia?
Pernicious anemia is due to a deficiency of a vitamin called intrinsic factor, which is normally produced by cells of the stomach. Intrinsic factor is required for the absorption of vitamin B12, so if intrinsic factor levels are insufficient, vitamin B12 will not be absorbed well. So administration of vitamin B12 will only help treat vitamin B12-deficiency anemia if vitamin B12 can be absorbed, and this can only happen if there are adequate levels of intrinsic factor to begin with. Patients with pernicious anemia do not have adequate intrinsic factor levels, so they will not be helped by vitamin B12 treatment since they can't absorb it well enough.
Pernicious anemia results from a combination of lack of intrinsic factor and?
atropic gastritis
What is the function of the intrinsic factor?
Intrinsic factor is necessary for the proper absorption of vitamin b12 which is necessary for red blood cell maturation, and therefore prevents pernicious anemia
What stomach secretion is necessary for normal hemoglobin Production in RBC's?
Intrinsic factor is secreted by the parietal cells and is critical for absorption of B12. When the body attacks the parietal cells b12 deficiency results which is called "pernicious anemia."
What cause pernicious anemia?
Pernicious Anemia is caused by a lack of intrinsic factor (usually). There can be other causes, such as infection, surgery, medicines taken, or diet.
What is pernicious anemia is cause by?
PA is caused by a deficiency of Intrinsic Factor (IF). IF is a required factor in Vitamin B12 absorption through the gastrointestinal tract. IF deficiency is diagnosed by Schilling's test, as well as Gastric IF analysis and clinical rpesentation (macrocytic megaloblastic anemia, often showing hypersegmented neutrophils, along with normal Folic acid levels).
What will the Lack of intrinsic factor result in?
A lack of intrinsic factor will result in impaired absorption of vitamin B12 in the intestines, leading to a condition called pernicious anemia. This can cause symptoms such as fatigue, weakness, and neurological issues if left untreated. Treatment often involves regular B12 injections to bypass the absorption issue.
Where does the absorption of vitamin B12 occur?
The vitamin B12 is a very important nutrient; it lowers risk of stroke, heart disease, cancer, Parkinson's, and Alzheimer's disease. The vitamin begins to absorb in the mouth, in contrast to most nutrients.
