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Doxorubicin kills cells primarily by intercalating into DNA, which disrupts the double helix structure and inhibits DNA replication and transcription. It also generates reactive oxygen species (ROS) that cause oxidative damage to cellular components. Additionally, doxorubicin can interfere with topoisomerase II, an enzyme crucial for DNA unwinding during replication, leading to double-strand breaks. Collectively, these mechanisms result in cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells.
What else can I help you with?
Is doxorubicin is water soluble?
Doxorubicin has a solubility of 10mg in 1 ml of water, which should be warmed slightly.
What has the author Heidi Traunecker written?
Heidi Traunecker has written: 'The biology of drug resistance in human sarcoma cells following a brief exposure to doxorubicin'
What is the dosage form of doxorubicin?
Intravenous
What is the antidote for Doxorubicin?
hyaluronidase
Can scarlet fever kill cells?
yes it can kill cells but it cannot kill you
How does doxorubicin affect DNA methylation?
Doxorubicin can induce changes in DNA methylation patterns by affecting the activity of DNA methyltransferase enzymes. It can lead to global hypomethylation or hypermethylation of specific gene promoters, influencing gene expression and potentially contributing to its cytotoxic effects.
Does cheese kill brain cells?
no cheese does not kill brain cells
Does lifetime dose of doxorubicin expire?
Yes, the lifetime dose of doxorubicin does have a limit, as it is associated with the risk of cumulative cardiotoxicity. Oncologists typically monitor the total lifetime exposure to doxorubicin, usually capping it at around 450-550 mg/m², depending on individual patient factors and concurrent treatments. Once this limit is reached, further administration can lead to significant heart damage. Therefore, careful management and assessment are crucial in chemotherapy regimens involving doxorubicin.
With doxorubicin admistration it is essential that the nurse closely monitor for the patients?
yes
What does nucleic acid do to cells?
it kill cells
Drugs containing primary amine as afunctional group?
Doxorubicin, an anticancer drug.
Does ink kill brain cells?
Ink does not directly kill brain cells. However, the metals and toxins in ink can kill brain and other cells and is not good for the body or your health as a whole.
