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During hyponatremia, brain tissue is particularly vulnerable due to its high water content and limited ability to regulate osmotic balance. When serum sodium levels drop, water shifts into brain cells, causing cellular swelling and potentially leading to cerebral edema. This swelling can result in increased intracranial pressure and neurological symptoms, distinguishing brain tissue's response from other tissues, which may have more robust mechanisms for handling osmotic changes. Additionally, the blood-brain barrier complicates the brain's ability to adapt to rapid fluctuations in sodium levels.

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