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From all I have read and studied (I am a 2nd semester senior nursing student at a major university) Spina Bifida is not so much a chromosomal defect as a neural defect caused by a lack of folic acid during the very early stages of pregnancy.

This is why women who wish to get pregnant are encouraged to begin taking folic acid BEFORE they actually get pregnant.

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11y ago
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13y ago

Spina bifida doesn't follow a strict inheritance pattern, but hereditary factors do play some role, though it is not completely understood yet.

Mothers who have had one child with spina bifida have a 3-4% chance of their next child having spina bifida, while the general population only has a 0.1-0.2% chance. In the case a pregnant woman has a family history of spina bifida, it is recommended that they take a higher dose of folic acid than other pregnant women. Here again, folic acid plays a role in preventing neural tube defects (like spina bifida), but the mechanism is not well understood.

Also, for an unknown reason, it is more prevalent in female children than in male children.

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13y ago

There has been no particular set of chromosomes that have been shown to cause spina bifida.

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13y ago

There has been no particular chromosome that has been shown to cause spina bifida.

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10y ago

It does not seem to be inherited. But if it runs in the family, your doctor should be told this. New research involves a gene: VABGL1.

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10y ago

Spina Bifida is not a chromosomal defect. Individuals born with Spina Bifida have the normal number of chromosomes, 46.

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