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Yes. Carcinogenesis is generally classified as being caused by either genotoxic events epigenetic events. Acid reflux damages the epithelial cells of the esophagus, and requires in increase in cell production and replication to correct the injury. As the cells are forced reproduce and repair the damage, the probability of a mislocation, or translational error increases. Similarly, the probability of some kind of tumour formation increases. There are several kinds of benign (non-cancerous tumors), however, in each case, the tumour may be thought of as a stepping-stone to "cell dedifferentiation" which may lead to cancer.

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