Epidermal dendritic cells
Macrophages in the skin play a key role in the body's immune response by engulfing and destroying pathogens and foreign substances. They also help to activate other immune cells and release signaling molecules to coordinate the overall immune response. This helps to protect the body from infections and maintain overall health.
skin, stomach acid, mucous membranes and endothelial tissues then Innate immune system which is cascade of reactions of some 25 proteins produced in the spleen and liver marking them to be eaten by immune cells called phagocytes (monocytes, neutrophils and macrophages)
skin and mucous membranes first line of defense second line-leukocytes and macrophages, inflammation and fever third is immune system
Yes, the dermis contains numerous macrophages, which play a crucial role in the immune response and tissue homeostasis. These immune cells help to identify and eliminate pathogens, debris, and dead cells, contributing to wound healing and inflammation. Additionally, macrophages in the dermis can interact with other immune cells and participate in the regulation of various skin conditions.
Epidermal dendritic cells (Langerhans cells) and macrophages serve as crucial components of the immune system, acting as barriers against pathogens. They are located in the skin and tissues, where Langerhans cells capture and present antigens to T cells, while macrophages phagocytose debris and pathogens. Together, they form the first line of defense by detecting and responding to infections, thus playing a vital role in both innate and adaptive immunity. Their presence helps maintain skin integrity and overall immune surveillance.
Almost everything. Respiratory system (lined with cilia and have macrophages, other immune cells, mucus-producing cells), GI system--the gut, starting from the mouth to the stomach to the bowels (lots of immune cells), lymph nodes (they're everywhere and drain every part of your body), thymus, spleen, bone marrow (produce white blood cells), skin .
No
yes
Macrophages are primarily found in the dermis, which is the layer of skin below the epidermis. They play a key role in the immune response and help protect the skin from pathogens and foreign invaders.
Leprosy, caused by the bacterium Mycobacterium leprae, has a life cycle that begins with transmission through respiratory droplets or skin contact, leading to infection primarily in the skin, peripheral nerves, and mucous membranes. Once inside the body, the bacteria invade and replicate within macrophages, evading the immune response. The immune system responds specifically by activating T cells that target the infected cells, while non-specific responses include the recruitment of macrophages and inflammation to contain the infection. However, in some cases, the bacteria can suppress the immune response, leading to the characteristic skin lesions and nerve damage associated with leprosy.
immune system