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What are the advantages of thalidomide?
the benifits of thalidomide are;high doses caused limb defects in the offspring of rabbits, but not other animals.it causes defects in humans by interfering with the growth and development of new blood vessels.
What teratogen causes severe limb deficiencies?
Thalidomide.
How did thalidomide affect babies?
Thalidomide caused severe birth defects in babies whose mothers took the drug during pregnancy. These birth defects included limb deformities, such as missing or malformed limbs, as well as other malformations of organs like the ears, heart, and digestive system. Thalidomide exposure during pregnancy led to a tragic and widespread public health crisis in the 1950s and 1960s.
What effect did thalidomide have on pregneant women?
Thalidomide, originally prescribed in the late 1950s and early 1960s as a sedative and anti-nausea medication for pregnant women, caused severe birth defects in thousands of infants. Babies born to mothers who took thalidomide often suffered from limb abnormalities, organ defects, and other serious health issues, a condition known as phocomelia. The drug's tragic impact led to stricter regulations on drug testing and approval processes for pregnant women. Its use in pregnancy has since been banned in many countries, although thalidomide is now used under strict controls for certain medical conditions.
What causes the thalidomide production of a baby with no arms or legs?
Thalidomide was prescribed for morning sickness in pregnancy before the devastating effects were known. Thalidomide affects angiogenesis which is the process in which new blood vessels form. By preventing the formation of these new vessels to take place, directly resulting in babies being born with no limbs.
When in pregnancy did thalidomide affect baby?
The thalidomide sensitive period goes from day 21 past conception onwards to day 42. (Dr Janet McCredie, "Thalidomide - Birth Defects Explained", London, The Royal Society of Medicine Press, 2007, p. 189 and many other places in the book} McCredie suggests, p. 126, that the hypothesis of neural crest injury is the underlying pathogenetic mechanism of many congenital malformations. And concludes, pp. 150 - 151, that the thalidomide-sensitive period coincides with neural crest development, but not with limb development That's what I understand. I have no knowledge of (human) biology and related sciences. I'm only a dumb thalidomide-monster.
What is the effect on babies by thalidomide?
Thalidomide, a drug initially prescribed for morning sickness in pregnant women during the late 1950s and early 1960s, caused severe birth defects in babies, including limb malformations, organ abnormalities, and facial deformities. Known as phocomelia, the most notable effect was the underdevelopment of arms and legs. The tragedy led to stricter regulations on drug testing and approval for pregnant women. Today, thalidomide is used under strict controls for certain conditions, but it remains a poignant reminder of the importance of drug safety.
What side effects are there for thalidomide?
Thalidomide was originally given to pregnant women who suffered from morning sickness, it is not also used to treat leprosy. Although it often cured women's morning sickness, it actually causes severe limb dis-configurements in newborn children.
Why were ' children of thalidomide' significant in 1958?
The "children of thalidomide" were significant in 1958 due to the public health crisis that emerged from the use of the drug thalidomide, which was prescribed to pregnant women as a sedative and to alleviate morning sickness. The drug caused severe birth defects, including limb malformations, leading to thousands of affected children worldwide. This tragedy raised awareness about the need for stricter drug regulations and the importance of rigorous testing for pharmaceuticals, ultimately resulting in significant changes in drug approval processes, particularly in the United States and Europe. The incident became a pivotal moment in the history of medical ethics and pharmaceutical safety.
Between 1957 and 1961 many pregnant women took thalidomide to alleviate morning sickness this drug disrupted what period of prenatal development?
Thalidomide primarily disrupted the period of embryonic development, particularly between the 4th and 8th weeks of pregnancy. During this critical time, the foundations for major organs and limbs are formed, leading to severe birth defects such as limb malformations and other developmental issues when the drug was taken. Its impact highlighted the importance of drug safety during pregnancy.
What is thalidomide?
Thalidomide is a drug that was prescribed to pregnant women in the 60's ish to relieve the symptoms of morning sickness that was later discovered to cause birth deformities (particularly malformed limbs). -a sedative and hypnotic drug; withdrawn from sale after discovered to cause severe birth defects because it inhibits angiogenesis -Thalidomide is a sedative-hypnotic, and multiple myeloma medication. The drug is a potent teratogen in rabbits and primates including humans -A drug that was sold during the late 1950s and 1960s as a sleeping aid, and to pregnant women as an antiemetic to combat morning sickness and ... -tranquilizing drug that can have a teratogenic effect on the auditory system of the developing embryo when taken by the mother during pregnancy ... -A drug being investigated for its potential as an angiogenesis inhibitor. -An emblematic example of a chemical applied to health. Its use in treating sickness during pregnancy in the 1960s resulted in birth defects. The birth defects were caused because thalidomide changes the growth and development of new blood vessels (angiogenesis) in the developing babies. ... -A drug rarely used because of its disastrous side effects in pregnancy, but proving useful in some lupus with severe skin lupus. -A drug to help morning sickness that was withdrawn in 1961 after it was found to cause limb deformities in babies born to women who had taken it -drug which is a powerful human teratogen. First synthesized in Germany in 1954 as a new antihistamine, the drug was found to be a safe.
Why is thalidomide not used for morning sickness?
Thalidomide is not used for morning sickness because it was infamously associated with severe birth defects when prescribed to pregnant women in the late 1950s and early 1960s. The drug caused limb malformations and other serious health issues in infants. While it has some therapeutic uses today, such as in certain cancers and autoimmune diseases, its risks during pregnancy far outweigh any potential benefits for treating morning sickness. As a result, safer alternatives are recommended for managing this condition.
