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Thalidomide was prescribed for morning sickness in pregnancy before the devastating effects were known. Thalidomide affects angiogenesis which is the process in which new blood vessels form. By preventing the formation of these new vessels to take place, directly resulting in babies being born with no limbs.

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9y ago
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10y ago

There are three theories how this drug works on developing fetuses:

1. The drug prevents blood vessel development. Since the limbs need a good supply, they do not fully form.

2. It inactivates a protein called cereblon. This protein is important in limb development.

3. Both

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Q: What causes the thalidomide production of a baby with no arms or legs?
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