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Exoenzymes are digestive enzymes that are secreted by the pathogen into the surrounding tissues, allowing the pathogen to further invade the host's tissues. For example, Streptococcus pyogenes secretes streptokinase to dissolve blood clots, allowing wound invasion, and streptolysin, which digests red blood cells and other body cells. Clostridium perfringens, an agent of gangrene, secretes a lipase that damages cell membranes, creating more dead tissue for these bacteria to invade.

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