Microbes evade the immune system through inhibition of phagocytosis by affecting the receptors that phagocytes use to engulf bacteria or by mimicking host cells so that the immune system does not recognize them as foreign.
Microbes, such as bacteria, viruses, fungi, and parasites, can cause illness by invading the body and disrupting normal physiological functions. They may produce toxins that damage tissues, evade the immune system, and multiply rapidly, leading to inflammation and infection. Additionally, some microbes can interfere with nutrient absorption or trigger harmful immune responses. The resulting symptoms can range from mild discomfort to severe disease, depending on the type and virulence of the microbe.
Two genera that can evade the human immune system by frequently changing their surface proteins are Plasmodium, the genus that causes malaria, and Influenza virus. Both of these pathogens possess mechanisms to rapidly alter their surface proteins (antigens) in order to evade host immune responses.
The immune system must attack the bodys own cells
Plasmodium and Trypanosoma
Sometimes chlamydia surface antigens change, and make it hard for the immune system to keep up. It also appears that chlamydia may release toxins that damage the immune response in some cases. (see related link).
Mucoid capsules prevent desiccation in some organisms which increase virulence. Capsules are slippery and can evade a human's immune system.
The plasmodium parasite moves through the host's bloodstream by changing its shape and gliding. This unique form of locomotion helps it avoid detection by the immune system.
The specific immune response that may not occur when Staphylococcus aureus enters the bloodstream is the activation of the complement system. This response involves a series of proteins that help to eliminate invading microorganisms, but certain strains of Staphylococcus aureus possess proteins that can inhibit or evade complement activation, allowing the bacterium to evade immune detection and destruction.
Leishmania lives within macrophages because it has adapted to evade the host immune system by exploiting the intracellular environment of these immune cells. By residing inside macrophages, Leishmania can avoid detection and destruction by the host's immune response, allowing it to establish a chronic infection.
The S bacteria possess a protective polysaccharide capsule that helps them evade the immune system, allowing them to survive and cause infection. The R bacteria lack this capsule and are easily targeted and eliminated by the immune system, thus they are not virulent.
Protozoa can evade the host immune system by changing their surface antigens to avoid detection and destruction. Some protozoa can also reside within host cells to escape immune detection, or they can suppress the host's immune response by secreting immunomodulatory molecules. Additionally, some protozoa can cause chronic infections by altering their replication rate to avoid being completely eradicated by the immune system.
Even if you don't want to get sick, you can't control getting sick. You get sick because a virus or bacteria happens to evade or resist your immune system, and your immune system cannot be controlled, so you get sick because your body temporarily doesn't have the ability to abolish the bacteria or virus that is in your body.