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The S bacteria are surrounded by a capsule, so it is not engulfed by the host's white blood cells. That means that it is able to proliferate and spread. The R bacteria lack the capsule (like the mutant S bacteria), so the white blood cells are able to detect and eliminate them.
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Frederick Griffith discovered the phenomenon wherein exogenous DNA of heat killed virulent bacteria was taken up by a similar but non-virulent bacteria. This resulted in the transformation of the living bacterial cells into the virulent variety. This was prior to the understanding that DNA was the genetic material and the hereditary information passed onto the living bacteria was referred to as the "transforming principle." Source : Russell "iGenetics : A Molecular Approach."
Virulent means actively poisonous. You could use it in a sentence as, "the man had a virulent snake bite."
This experiment was conducted by Frederick Griffith in 1928. He observed that when he mixed a harmless strain of bacteria with a heat-killed virulent strain, the harmless bacteria were transformed into a virulent form. This led to the hypothesis that something in the heat-killed bacteria had transformed the live bacteria.
The live R bacteria acquired a capsule and became live, virulent S bacteria.
The live R bacteria acquired a capsule and became live, virulent S bacteria.
Griffith hypothesized that a chemical component from the virulent S cells had somehow transformed the R cells into the more virulent S form.
Fred Griffith found that genetic information could be transferred between different strains of bacteria, specifically between the harmless R strain and the virulent S strain of bacteria. This led to the discovery of transformation, a process where genetic material is exchanged between bacteria.
The S bacteria are surrounded by a capsule, so it is not engulfed by the host's white blood cells. That means that it is able to proliferate and spread. The R bacteria lack the capsule (like the mutant S bacteria), so the white blood cells are able to detect and eliminate them.
The molecule that caused transformation in Griffith's pneumonia experiment was DNA. Specifically, it was the transfer of DNA from heat-killed virulent bacteria to live non-virulent bacteria that resulted in the transformation of the non-virulent bacteria into a virulent form.
Griffith's transformation experiments, conducted in 1928, involved studying two strains of Streptococcus pneumoniae in mice: a virulent smooth strain (S) and a non-virulent rough strain (R). He discovered that when he injected mice with heat-killed S strain bacteria mixed with live R strain bacteria, the mice developed pneumonia and died. This indicated that some "transforming principle" from the dead S strain had converted the live R strain into a virulent form. Griffith's work laid the groundwork for later discoveries about DNA as the genetic material.
Virulent bacteria are ones that are able to cause disease. Examples of potentially virulent bacteria are Staphylococcus aureus and Neisseria gonorrhea.
this bacteria is virulent strain
The discovery that DNA is the chemical responsible for transforming live R cells in mice is credited to Frederick Griffith. In his 1928 experiments with Streptococcus pneumoniae, Griffith demonstrated that non-virulent R strain bacteria could be transformed into virulent S strain bacteria when exposed to heat-killed S strain. This transformative principle was later identified as DNA by Avery, MacLeod, and McCarty in 1944.
The S strain of bacteria is virulent due to its ability to produce a protective capsule that helps it evade the host's immune system, allowing it to cause disease in animals. In contrast, the R strain lacks this capsule and is non-virulent, meaning it cannot effectively evade the immune response and does not cause disease. This difference in pathogenicity is a key factor in understanding bacterial infections and their effects on host organisms.
Griffith's experiments, conducted in the 1920s, demonstrated that non-virulent strains of Streptococcus pneumoniae could be transformed into virulent strains when exposed to heat-killed virulent bacteria. He observed that when live non-virulent bacteria were mixed with the heat-killed virulent bacteria, some of the non-virulent bacteria took up the hereditary material from the dead bacteria, becoming virulent themselves. This transformation indicated the presence of a "hereditary factor" that carried the information necessary for virulence, laying the groundwork for the later discovery of DNA as the genetic material.